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ExecuNet

VP Chemistry

Post Date:Jul 07, 2020Type:Full-Time
Start Date:7/7/2020Salary:
Location:US-WA-Bothell Job Reference:621564
Skills:
 

Job Description:

We are seeking a highly motivated, innovative and experienced leader to head our chemistry group.  This position will involve oversight of the chemistry efforts within research at Company. This includes leading the discovery and development of novel antibody drug conjugate (ADC) technologies that will advance the field of targeted cancer drug delivery, including new payload mechanisms of action and conditional drug release mechanisms that improve drug potency, therapeutic efficacy, and specificity.  The successful candidate will also work with senior leadership in Research and to build new capabilities within the Chemistry group that complement the ADC platform, and expand our expertise in small molecule targeted cancer drug discovery and development. 

Responsibilities: 

  • Lead a group of highly skilled and experienced chemists who are focused on targeted anticancer drug delivery
  • Extend the research scope in areas of novel drug mechanisms of action that complement existing technologies and approaches
  • Expand efforts towards optimizing new drugs for targeted delivery and targeted cancer drug discovery and development
  • Explore new ADC drug linkers and drug carriers designed to enhance ADC biologic and pharmacologic properties
  • Initiate efforts directed towards improving the therapeutic windows of targeted drug delivery strategies beyond those achieved with existing delivery systems
  • Collaborate with Antibody Discovery, Cancer Biology, Immunology and Protein Sciences groups to develop new targeted drug discovery strategies
  • Position research programs within Chemistry for development, and establish strong alliances with Process Sciences, Process Chemistry and other groups within Company to assure that promising new molecules advance expeditiously towards clinical trials
  • Establish strategic relationships with biotech, pharma, and key academic groups that have technologies that complement the ongoing efforts within Chemistry
  • Extend the expertise within Chemistry to drug classes that are ideally suited for applications in immune oncology
  • Contribute to appropriate Intellectual Property strategies for the protection of new discoveries
  • Generate a robust publication record in leading journals, and present findings at key meetings
  • Foster a culture of collaboration, innovation, discovery, and cutting-edge research

Qualifications:

  • A deep knowledge of drug discovery and development including a track record of advancing novel drugs through early phase discovery into pre-clinical and clinical development
  • Expertise in the discovery and development of targeted drugs for cancer, including a broad understanding of the field and the challenges it faces
  • A history in the targeted delivery of cancer drugs, including experience with antibody drug conjugates or other targeted delivery systems is a plus
  • Proven leadership skills with a track record of leading medium to large groups and the ability to work effectively with other groups throughout the company
  • A track record of successfully building research groups, hiring talented scientists and developing their careers
  • Lead multidisciplinary scientific teams in developing new programs and projects, providing clear direction to research efforts that align with Research departmental goals and long term strategy
  • Membership of scientific societies or scientific achievement awards. A distinguished publication and patent record, reflecting innovation and a series of outstanding discoveries
  • Collaborate with the Research Leadership Team to drive discoveries in biological and pharmaceutical research; to innovate new products and novel technologies; and to build research and innovation strategies and infrastructure
  • Develop and execute research and early project plans that will systematically address multiple target and indication opportunities
  • Create and execute overall chemistry plan to ensure robust, cost-effective support of company discovery and development portfolio

Education:

  • A PhD in chemistry or related field with significant background in organic synthesis, analytical technologies, and bio-organic chemistry




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